Gemfibrozil dosage

Renal failure is a relative contraindication to the use of fibric acid agents, as is hepatic dysfunction. Combined statin-fibrate therapy should be avoided in patients with compromised renal function. Gemfibrozil should be used with caution and at a reduced dosage to treat the hyperlipidemia of renal failure. Fibrates should not be used by children or pregnant women. 

Fibrates An interaction of gemfibrozil with warfarin has been described in a 62-year-old man, whose INR rose to 5.8 within 3 weeks of the addition of gemfibrozil 600 mg bd. The authors recommended a dosage reduction of 20% and close monitoring during administration of this combination [39. ... 

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