Gatekeeper tumor suppressors

Adenomatous polyposis coli (APC) gene A tumor suppressor gene, acting as a gatekeeper to prevent development of tumors. A familial cancer syndrome called FAP, or familial adenomatous polyposis, is caused by mutations in APC. Mutation of APC also occurs commonly in sporadic cases of colorectal carcinoma. 

Tumor suppressor genes, like oncogenes, also have a role in cell proliferation, but function as gatekeepers and govern the dynamics of cell proliferation. 

---