Gastroesophageal adenocarcinoma

Goekkurt E, Al-Batran SE, Hartmann JT et al (2009) Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin a study of the arbeitsgemeinschaft internistische onkologie. J Clin Oncol 27 2863-2873... 

Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999 340 825-831. 

Although there are efforts at this time to stratify squamous vs adenocarcinoma, studies to date have not separated these two histologies and, therefore, treatment recommendations have been similar, regardless of histology. The only exception to this generalization is adenocarcinomas of the gastroesophageal junction. 

Although only reported in abstract form, INTO 116, a randomized study of postoperative modality therapy (5-FU, leucovorin, and RT) vs surgery alone in resected adenocarcinoma of the stomach and gastroesophageal junction, has found a statisti-... 

Safran H, et al. Paclitaxel and concurrent radiation therapy for locally advanced adenocarcinomas of the pancreas, stomach, and gastroesophageal junction. Seminars inRadiation Oncology 1999 9(2 Suppl l) 53-57. 

Macdonald JS, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001 345(10) 725-730. 

Esophageal adenocarcinomas do not appear to be as responsive [171]. Ajani et al. [172] have studies neoadjuvant EAP (VP-16, doxorubicin, and cisplatin) for patients with adenocarcinomas of the distal esophagus and gastroesophageal junction and observed a 42% response rate 78% of treated patients underwent curative resection and overall median survival was 23 months. 

Valle, J. W, Armstrong, A., Newman, C., Alakhov, V, Pietrzynski, G., Brewer, J., Campbell, S., Corrie, P, Rowinsky, E. K. and Ranson, M. (2011) A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction. Invest New Drug, 29,1029-1037. 

Fig. 6.2.14a,b. Direct invasion of the stomach by neighbouring tumour, a Oblique coronal reformation through the pancreas demonstrates the direct invasion of the stomach by an adenocarcinoma of the pancreatic tail (arrow). There is a splenic infarct (white arrowhead) and splenic hypoperfusion (black arrowhead) due to tumour obstruction of the splenic artery and vein, b Parasagittal reformation through the gastroesophageal junction demonstrates surgical proved direct infiltration of the stomach by oesophageal carcinoma (arrows)... 

Safran, H., Akerman, P., Cioffi, W., Gaissert, H., Joseph, P., King, T., Hesketh, P.J., Wanebo, H. Paclitaxel and concurrent radiation therapy for locally advanced adenocarcinomas of the pancreas, stomach, and gastroesophageal junction. Semin. Radiat. Oncol. 9(2), 53-57 (1999)... 

---