Gastric migrating motor complex

Shindo et al. [66] treated 19 healthy volunteers with omeprazole 20 mg, cultured gastric and jejunal aspirate, and determined gastric pH and bile acid metabolism. Although motility studies were not performed, it can be assumed that intestinal migrating motor complexes were normal [21] (fig. 4). Bacterial colonization was defined by species density exceeding 105 CFU/0.5 ml, and only reported for those exceeding this limit. 

Macrolide antibiotics such as erythromycin directly stimulate motilin receptors on gastrointestinal smooth muscle and promote the onset of a migrating motor complex. Intravenous erythromycin (3 mg/kg) is beneficial in some patients with gastroparesis however, tolerance rapidly develops. It may be used in patients with acute upper gastrointestinal hemorrhage to promote gastric emptying of blood before endoscopy. 

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