Gastric carcinogenesis inhibition

Mirvish (53,54) discovered that vitamin C could inhibit ni-trosation reactions. The purely chemical interaction of ascorbic acid with nitrite has been studied for theoretical reasons and because of its importance in the preservation of foods. This interaction has received increased attention for minimizing the presence of nitrosamines and nitrosamides in the environment, and especially in foods. We have studied the relationship in gastric carcinogenesis between high levels of nitrite, including pickling, and of vitamin C as a protective and inhibiting element. 

Carcinogenesis inhibition. Polysaccharide fraction of the dried seed hulls, administered to rats by gastric intubation, was active vs tumor induction with N-ethyl N-nitro-N nitrosoguanidine h Rice bran, administered orally to male rats at a concentration of 4% of the diet, was active. A 1 1 combination of wheat bran and psyllium, at a total level of 8% dietary fiber, offers the highest protection against colon tumor development . 

Wasabi Eutrema wasabi Maxim.) inhibited A-methylnitrosourea A-methyl-A -nitro-A-nitrosoguanidine-induced rat gastric carcinogenesis. Pretreatment of A/J mice with... 

Uedo, N., Tatsuta, M., lishi, H. et al. 1999. Inhibition by d-limonene of gastric carcinogenesis induced by Af-methyl-A -nitro-A -nitroguanidine in Wistar rats. 137 131-136. 

Stomach as a consequence of bacterial overgrowth after inhibition of acid secretion by omeprazole has not been found. Therefore, an important step in the Correa hypothesis of gastric carcinogenesis is lacking. Obviously, achlorhydria as an isolated factor is not enough to initiate gastric carcinoma [73]. 

Although cancer cell lines are a valuable tool for the study of new antitumor agents, in vivo experiments must also be performed in order to verify their efficacy. Polyphenols were found to inhibit in vivo breast, prostate, skin, nasopharyngeal, colon or gastric tumor xenografts in athymic and severe immunodeficient mice, the DMBA-induced breast or colon carcinogenesis, and the development and progression of prostate cancer in the TRAMP model. 

The chemopreventive effects of milk thistle have been investigated in various studies. Silybin was found to protect the following organs from chemical- or radiation-induced toxicides rat cardiac muscle cells, kidney cells of rats and monkeys,skin cells of mice, and rat gastric mucosa and pancre-as.3 3 Silymarin was also found to inhibit carcinogenesis in rat colon cells,mice urinary bladder, rat tongue cells, and human breast cancer cells. ... 

Particularly interesting is the observation made by Cao et al. (2008) that canolol is able to inhibit the inflammatory process in gastric mucosa and the subsequent formation of gastric tumours by repressing the expression of inflammatory cytokines. In this context it should be determined if canolol can also inhibit tumour development in those experimental models of liver and intestinal cancer, in which carcinogenesis is preceded or accompanied by inflammation. 

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