Mixed micelles gangliosides

The rate of formation of mixed micelles of two ganglio-sides was found to be very slow, with a time constant of about 3 hours. In these experiments, two micellar solutions of two different gangliosides were mixed, and the change of scattered intensity with time reflected the hybridization of the micelles. Such very large values of T2 are in line with the very small values of k" reported for gangliosides (see Section III.B.ll). When one of the two micellar solutions of ganglio-side was replaced by a solution of Triton XlOO, a conventional nonionic surfactant, the rate of hybridization was very fast. 

Figure 3. Physicochemical features of mixed aggregates of phosphatidylcholine, phosphatidylethanolamine (PE, used as surface marker), and gangliosides (Gut, G ,a, GTlb, Gt),b) at increasing proportions of ganglioside. Highest value of the outer PE/total PE ratio corresponds to liposomes. Lowering of turbidity and concurrent enhancement of ratio indicate presence of micelles. Break point is indicated as the transition ganglioside/ phospholipid molar ratio. ...

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