Gallstones amorphous pigment stones

Shioda (82) investigated the effect of dietary constituents on gallstone formation in golden hamsters. Like Dam, he found that hamsters on a low-fat diet frequently formed cholesterol gallstones. The addition of unsaturated fats (codliver oil, sesame oil) prevented cholesterol stones but allowed the development of amorphous pigment stones. Cholesterol stones correlated well with increased cholesterol and decreased bile acids and phospholipids in hepatic bile that was consequently supersaturated with respect to cholester-... 

Raw starch (/5-starch) protected against gallstones, but when predigested with enzymes (83) or cooked (84) the starch (a-starch) became absorbable and the incidence of cholesterol stones was as great as in animals on the glucose, fat-free diet. The addition of neomycin to the a-starch, butterfat, 1 % cholesterol diet protected completely against cholesterol stones but resulted in a 100% incidence of amorphous pigment stones (84). 

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