Tramadol Gabapentin

Pharmacologic treatment of RLS includes dopaminergic agents, benzodiazepines, opioids, or anticonvulsants. In mild cases of RLS, benzodiazepines may be first-line agents. Clonazepam, lorazepam, triazolam, and temazepam have been effective. Clonazepam 0.5 to 2 mg is most frequently studied. Opiates such as methadone 5 to 20 mg, codeine 30 to 120 mg, and oxycodone 2.5 mg are very effective, but the development of tolerance is a concern. Abuse potential with opiates is also a concern due to the chronic nature of the condition. Other agents that have been used include apomorphine, amantadine, tramadol, magnesium, oxycodone, propoxyphene, gabapentin, bromocriptine, clonidine, and carbamazepine. Tolerance may de-... 

A study in animals reported a synergistic antinociceptive interaction between tramadol and gabapentin. ... 

The effects of a single preoperative dose of gabapentin 600 mg 2 hours preoperat-ively on postoperative pain and tramadol consumption after minilap open cholecystectomy have been assessed in a doubleblind study in 120 adults [163 ]. Sedation was common, and the incidence of postoperative nausea and vomiting was significantly reduced by gabapentin. 

Srivastava U, Kumar A, Saxena S, Mishra AR, Saraswat N, Mishra S. Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy a randomized double-blind, placebo-controlled trial Eur J Anaesthesiol 2010 27(4) 331-5. 

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