GabaA structure-activity studies

Tronchet et al. studied the anti-HIV and cytotoxic activities of a heterogeneous series of l-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) analogues and established SAR models suitable for VHTS using a Hansch-type approach, a neural network approach, and a pharmacophore search method (CATALYST ) (50). Maddalena and Johnston carried a similar study on compounds acting at benzodiazepine y-aminobutyrie acid A (GABAa) receptor preparations (51). They found that a suitably optimal ANN pharmacophore model represented the internal physieoehemieal structure of the receptor site. 

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