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GABAa receptors changes

Tobler I, Kopp C, Deboer T et al (2001) Diazepam-induced changes in sleep role of the al GABAa receptor subtype. Proc Natl Acad Sci USA 98 6464 6469... [Pg.254]

Figure 11.5 Chloride distribution and the GABAa response. The change in membrane voltage (Fm) that results from an increase in chloride conductance following activation of GABAa receptors is determined by the resting membrane potential and the chloride equilibrium potential (Fci)- (a) Immature neurons accumulate CF via NKCC, while mature neurons possess a Cl -extruding transporter (KCC2). (b) In immature neurons GABAa receptor activation leads to CF exit and membrane depolarisation while in mature neurons the principal response is CF entry and h5q)erpolarisation. This is the classic inhibitory postsynaptic potential (IPSP)... Figure 11.5 Chloride distribution and the GABAa response. The change in membrane voltage (Fm) that results from an increase in chloride conductance following activation of GABAa receptors is determined by the resting membrane potential and the chloride equilibrium potential (Fci)- (a) Immature neurons accumulate CF via NKCC, while mature neurons possess a Cl -extruding transporter (KCC2). (b) In immature neurons GABAa receptor activation leads to CF exit and membrane depolarisation while in mature neurons the principal response is CF entry and h5q)erpolarisation. This is the classic inhibitory postsynaptic potential (IPSP)...
Lancel M., Faulhaber J., Holsboer F., Ruppert R. (1996). Progesterone induces changes in sleep comparable to those of agonists GABAA receptor modulations. Am. J. Physiol. 34, E763-72. [Pg.455]

Hutcheon, B., Morley, P., and Poulter, M. O. (2000) Developmental change in GABAa receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J. Physiol. 522, 3-17. [Pg.106]

Tia, S., Wang, J. F., Kotchabhakdi, N and Vicini, S. (1996) Developmental changes of inhibitory synaptic currents in cerebellar granule neurons role of GABAa receptor a6 subunit.. /. Neurosci. 16, 3630-3640. [Pg.110]

GABAa receptor al subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons../. Neurosci. 21,3009-3016. [Pg.110]

Bera AK, Chatav M, Akabas MH. 2002. GABAa receptor M2-M3 loop secondary structure and changes in accessibility during channel gating. J Biol Chem 277 43002-43010. [Pg.452]

Bouilleret V, Loup F, Kiener T, Marescaux C, Fritschy JM (2000) Early loss of internemons and delayed subunit-specific changes in GABAA-receptor expression in a mouse model of mesial temporal lobe epilepsy. Hippocampus 10 305-324... [Pg.240]

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GABAa receptors

GabaA

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