Future probiotic studies

Survival of probiotics imder various physicochemical conditions that are imposed during both processing and after intake (in the gastrointestinal tract) varies between strains. This needs further explanation and inter-species differences more fuUy determined and explained. This will lead to focusing upon the most reliable strains. For probiotics, nomenclature (taxonomical changes), poor stability and inaccurate labelling make sound conclusions difficult. Similarly there is no consensus on what constitutes a transient, persistent or colonizing effect within the gut flora. 

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The use of AAAs as feed supplements appears an attractive approach either in itself or in combination with pro-, pre- and synbiotics, but the lack of animal feeding studies in which the efficacy of this approach could be determined makes it difficult to assess to what extent a two-barrier (targeting control at both the stomach and intestinal level) approach is commercially feasible. Also, since the viability of probiotics may also be affected by the use of AAA to increase the disinfection activity of the stomach, probiotics may need to be formulated in a way that protects them during stomach transfer. However, its potential should be determined in future research. 

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