Fusidium Fusidic acid

Fusidic acid is a product of, among others, the fungus Fusidium coccineum. It has a steroidal structure and has mainly bacteriostatic activity. Its mechanism of action is based on inhibition of bacterial protein synthesis. Its indications are limited to the treatment of severe staphylococcal infections, usually in combination with another antistaphylococcal agent to prevent the emergence of resistance. 

A number of triterpenoids are bioactive compounds and are used in medicine. For example, fusidic acid is an antimicrobial fungal metabolite, isolated from Fusidium coccineum, and cytotoxic dimeric triterpenoids, crellastatins, are isolated from marine sponges Crella species. 

The finding169 that a 2-pro-S hydrogen from MVA was lost during the formation of fusidic acid (99) by the mould Fusidium coccineum may provide evidence for the intermediacy of a A20(22)-sterol (100) however, (99) biosynthesized from (3RS,2R )-[2-14C, 2-3H]MVA and its (2S)-isomer each contained an atom of tritium at C-22, a result which excludes the possibility of (100) as a precursor. 

Fusidic Acid Fusidium coccineum Fusidic acid, antibacterial agent... 

Nine minor cometabolites (27)—(35) of the important antibiotic fusidic acid from the fungus Fusidium coccineum have been identified. Structure-activity relationships among fusidic acid type antibiotics have been reviewed.10a-Cucurbita-5,24-dien-3/3-ol (36) have been isolated from Lagenaria leucantha (Cucurbitaceae). The n.m.r. spectra of various cucurbitacins have been discussed. ... 

Fusidic acid a tetracyclic triterpene antibiotic, 516.69, m.p. 192 °C, [a]g>-9° (CHCI3). F.a. is isolated from culture filtrates of Fusidium coccinium. Like the structurally related antibiotics. Cephalosporin Pj... 

Although fusidic acid, C3iH480g, a metabolite of Fusidium coccineum and Cephalosporium lamellaecola, has been known for many years, it is only recently that a complete structure (I) has been proposed for this antibiotic (Arigoni et al., 1964 Bucourt and Legrand, 1964). There is still room for doubt regarding some... 

Ebersole, R. C., W. O. Godtfredsen, S. Vangedal, and E. Caspi Mechanism of Oxidative Cyclization of Squalene. Concerning the Mode of Formation of the 17(20) Double Bond in the Biosynthesis of Fusidic Acid by Fusidium coccineum. J. Amer. Chem. Soc. 96, 6499 (1974). 

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