Furosemide Paracetamol

Sotalol, metoprolol, propranolol, carvedilol, nifedipine, captopril, cilazapril, milrinone, ticlopidine, acenocoumarol, furosemide, acetylsalicylic acid, salicylic acid, ibuprofen, naproxen, ketoprofen, diclofenac, paracetamol, dipyrone, mildronate, sildenafil, dexa-methasone, carbamazepine, terbinafine/urine UHPLC MS/MS Column Zorbax Rapid Resolution High Definition SB-C18 (50 x 2.1 mm, 1.8 pm) Mobile phase Solvent A 0.1 % HCOOH in water Solvent B MeOH (gradient elution) Detection MS/MS, ionization ESI Protein precipitation LOQ 0.05-0.60 ng/mL [71]... 

Enalapril, paracetamol, sotalol, dipyrone, vancomycin, captopril, fluconazole, cefazolin, metoprolol, aspirin, ticlopidine, prednisolone, propranolol, digoxin, sildenafil, furosemide, dexamethasone, carvedilol, ketoprofen, nifedipine, terbinafine, acenocoumarol, spironolactone/urine HPLC DAD Column LiChroCART Purospher STAR, RP-18e (250 x 4 mm, 5 pm) Mobile phase MeOH ACN 0.05 % TFA in water (gradient elution) Detection DAD X = 200 50 nm Adjusted to pH 7.0, protein precipitation LOD 0.01-1.44 pg/mL LOQ 0.04-4.35 pg/mL [72]... 

Paracetamol, furosemide, dipyrone, cefazolin and dexamethasone/urine DPV Working electrode HMDE and graphite Reference electrode Ag/Ag/Cl Supporting electrolyte Britton-Robinson buffer (pH 2.4) Extraction SPE/column SPE NH2/elution MeOH Extraction LLE/ethyl acetate LOD 0.20-2.57 pM LOQ 0.53-6.28 pM [86]... 

The binding of drug to tissue is usually reversible. In some cases, however, there is covalent binding, which by definition is not reversible. This applies to drug or metabolite and could be important because it could be related to toxicity. " A good correlation has been reported in animals between the degree of covalent binding to hepatic protein and the severity of hepatic necrosis of paracetamol, isoniazid, adriamycin, and furosemide. " ... 

A 58-year-old man took sirolimus 8mg/m /day for severe psoriasis with arthritis. He also took ibuprofen, co-trimoxazole, and paracetamol. Within 1 month he developed nocturnal fever, dizziness, orthostatic hypotension, leg edema, and anemia. All his symptoms subsided after sirolimus withdrawal, furosemide treatment, and erythrocyte transfusion. 

Recently, sodium bicarbonate has been used as a gasforming agent in alginate raft systems and in floating, controlled-release oral dosage forms of furosemide and cisapride. Tablet formulations containing sodium bicarbonate have been shown to increase the absorption of paracetamol, and improve the stability of levothyroxine. ... 

In 10 healthy women paracetamol 1 g four times daily for 2 days was found to have no effect on the diuresis or natriuresis in response to intravenous furosemide 20 mg. ... 

An aqueous extract of rosemary enhanced the permeability of Caco-2 cells to furosemide but not verapamil, meto-prolol, ketoprofen, or paracetamol (Laitinen et al. 2004). 

Since the pioneering work of the Millers (1) and Magee and Barnes (2), it has become increasingly evident that many stable chemicals are metabolized to electrophilic intermediates that alkylate and arylate tissue macromolecules. This laboratory (3 -5) has shown that drugs, such as acetaminophen (paracetamol), phenacetin, furosemide (frusemide), isoniazid, and iproniazid, also are oxidatively activated by microsomal enzymes to electrophilic intermediates that covalently bind to tissue macromolecules and cause massive tissue necrosis. 

---