Furosemide hyperthermia

An 18-year-old woman with Mycoplasma pneumoniae infection complicated by pulmonary hyfpertension, cryoglobulinemia, and rhabdomyolysis developed hyperthermia, a tachycardia, and dermal blisters. Therapy at the time of onset included a continuous infusion of furosemide. Furosemide and other medications were withdrawn and within 2 days the adverse reactions resolved. She was then rechallenged with two doses of furosemide... 

Ebdrup L, Pedersen CM, Andersen MH, Storgaard M. Prolonged hyperthermia from furosemide infusion—a case report. Eur J Clin Pharmacol 2010 66(2) 215-6. 

Body temperature Repeated bouts of hyperthermia with skin bhsters occurred in an 18-year-old girl with a severe Mycoplasma pneumoniae infection during hemodialysis and continuous infusion of furosemide and other drugs [48 ]. When the medications were withdrawn, the hyperthermia resolved within 2 days. After rechallenge with two intravenous doses of furosemide 5 mg, there was an almost simultaneous increase in heart rate and temperature and the blisters reappeared. 

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