Furanocoumarins chemical structures

Figure 5.8. Some members of the furanocoumarins family of NPs showing the key feature (red) shared by each structure that allows each to react chemically with some nucleic acid and proteins. Possessing hiological activity due to an inherent chemical reactivity is very rare among NPs for reasons explained in the text.

Fig. 5.16. Structures, 13C chemical shifts (in ppm) and one-bond carbon-hydrogen coupling constants (in IIz, italic types) of coumarin (left side) and the furanocoumarin psoralen (right side).

Most of the common classes of coumarin systems have been synthesized although routes to furanocoumarins in high yield continue to be of interest. Most synthetic effort in the past decade has centered on isopentenyl substituted coumarins, due largely to Murray and his students. In common with many other groups of natural products, emphasis in coumarin chemistry has shifted away from purely chemical matters of isolation, structure and synthesis to areas of... 

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