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Fungal growth ergosterol

Azoles inhibit 14-a-sterol demethylase, a microsomal CYP that is essential for ergosterol biosynthesis (Figure 48-1). This results in the accumulation of 14-a-methylsterols that disrupt the packing of acyl chains of phospholipids and impair the functions of membrane-bound enzymes such as ATPase and those of the electron transport system, resulting in inhibited fungal growth. [Pg.801]

Mechanism of Fungal Growth Suppression by Inhibitors of Ergosterol Bio thesis... [Pg.268]

Weete, J. D. 1987. Mechanism of fungal growth suppression by inhibitors of ergosterol biosynthesis, pp. 268-285 in Ecology and Metabolism of Plant Lipids (G. Fuller and W. D. Nes, eds.) ACS Symposium Series 325, Washington, D. C. [Pg.416]

The effect of Voriconazole (10) is exerted within the fungal cell membrane. In particular, cytochrome P450-dependent 14-a-lanosterol demethylase is inhibited, which prevents the conversion of lanosterol (217) to ergosterol (218) - an important component of yeast and fungal cell membranes which does not occur in mammalians (Scheme 51). This mechanism results in the accumulation of toxic methylsterols and inhibition of fungal cell growth and replication [174]. [Pg.626]

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Ergosterol

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