Functionalized Polymers for Medical Applications

Preparation of Poly(Monooleoyl Glyceride-co-Maleic Anhydride) 

A reactor was charged with monoleoyl glycerol (142.6 g) and then heated to 140°C and treated with maleic anhydride (39.2 g). The reaction mixture was further heated to 

190°C for 3 hours and cooled to ambient temperature. The product was isolated as a pale yellow viscous hquid having a M of 1383 daltons and a M of 6435 daltons. 

A mixrnre consisting of the Step 1 product (5.0 g), 0.85 ml of mercaptoethylamine, 11 mlofDMF,and2,2 -azobisisobutyronitrile(54mg)washeatedto60°Cfor24hours and then cooled to ambient temperature. The polymer was diluted with 10 ml of EtOAc, washed once with 0.01 M of NaOH, twice with brine, dried with MgS04, and filtered. The solution was concentrated, and the product was isolated as a yellow, transparent viscous liquid. 

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