Functionalized Grignard reagents amination

Scheme 2-75. Preparation of secondary amines via the addition of functionalized Grignard reagents to aromatic nitro compounds.

Sihcon chemistry also provides a means for preparing dendrimers capped with metal ions [3,65]. For example, ferrocene [78,79], Co +, [80], Ru [81], and [9] have been hnked to the periphery of sihcon-based dendrimers. These materials are prepared by displacing reactive Si-Cl functional groups with any of a variety of nucleophiles, such as amines, alcohols, or Grignard reagents, containing the metal complexes or hgands. 

The cyanohydrin not only adds an additional C at the site of the C==0 but also introduces two new functional groups, OH and CN. which can be used to introduce other functional groups. The OH can be used to form an alkene (C=C), an ether (—RO), or a halogen compound (C—X) the C N can be reduced to an amine (CHjNHj), be hydrolyzed to a carboxyl (COOH) group, or react with Grignard reagents if the OH is protected. 

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