Functional groups, determination halogenation methods

Another traditional method used for polymer support characterization is elemental analysis. Its use as an accurate quantitative technique for monitoring solid-phase reactions has also been demonstrated [146]. Microanalysis can be extremely valuable if a solid-phase reaction results in the loss or introduction of a heteroatom (usually N, S, P or halogen). In addition, this method can be used for determination of the loading level of a functional group (e. g. usually calculated directly from the observed microanalytical data). For example, in many cases, the displacement of chloride from Merrifield resin has been used as a guide to determine the yield of the solid-phase reaction. 

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