Fullerene neuroprotection

Dugan LL, Lovett E, Cuddihy S, Ma B-W, Lin T-S, Choi DW (2000) Carboxyfullerenes as neuroprotective antioxidants. In Kadish KM, Ruoff RS (eds.) Fullerenes Chemistry, Physics, and Technology. Wiley, New York, pp. 467 479. 

In this contribution we want to provide a short overview addressing the current state-of-the-art of water-soluble fullerene derivatives and their potential applications as antioxidant or neuroprotective drug candidates. After summarizing the most prominent concepts of designing water-soluble fullerenes in the first chapter we will present some more recent achievements with respect to biological activities of antioxidant fullerenes, with emphasis on our own results. 

Fullerenes Radioisotope delivery to tumor cells, MRI contrast agents Antibacterial, neuroprotective, inhibition of HIV activity... 

Fullerenes have also been shown to possess myriad biological effects such as inhibition of HIV, antibacterial activity, and neuroprotection (21). Therefore, whether or not fullerenes are classified as drugs or excipients depends upon the indication for which they are used. 

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