Full pharmacokinetic screen

Another option, the so-called full pharmacokinetic screen, is to sample at fixed times relative to dosing within a single dosing interval such as with a traditional Phase 1 study. For example, Preston et al. (1998) reported such a design in their PopPK analysis of levo-floxacin in 313 subjects with bacterial infections of the respiratory tract, skin, or urinary tract. Therein samples were collected at end of infusion, 2, 6.75, 7.75, and 9.25 h after the third intravenous dose. What made intensive sampling possible in this case was that these subjects were at the hospital already. In general, if the disease state requires hospitalization then intensive sample collection is less a problem than if the subject is treated in an out-patient manner. 

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