1-fucosyl fluoride derivative

SnCI2-AgX The L-fucosyl fluoride derivative 18 reacts with glycosyl acceptor 19 in the presence of SnCl2-AgC104 to give the corresponding disaccharide 20 as a-anomer only (Scheme 2.7) [84],... 

Some 1,2-anhydro-aldofuranose derivatives (e.g. 15) have been prepared by base treatment of 2-O-tosylates. D-Mannose has been converted into the glycosyl chloride 16 from which the 1,2-anhydro derivative 17 was obtained. Similarly, the D-fucosyl chloride 18 was converted to the 1,2-anhydride 19 via the corresponding P-fluoride. Tri-O-acetyl-D-glucal and -galactal have been epox-idized (Scheme 3) to give 1,2-anhydro-compounds 20 and 21 respectively as the major products, and use of a 1,2-anhydro-hexopyranose in the synthesis of an antifungal furanone glycoside is covered in Chapter 3. 

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