Frustrated Lewis pair metal-free

Stephan, D. W. Erker, G. Frustrated Lewis Pairs Metal-Free Hydrogen Activation and More. Angew. Chem. Int. Ed. 2010, 49, 46-76. 

Stephan DW, Erker G (2010) Frustrated Lewis pairs metal-free hydrogen activation and more. Angew Chem Int Ed 49 46-76, Angew Chem 122 50-81... 

Frustrated Lewis Pairs A Metal-Free Strategy for Hydrogenation Catalysis... 

I 77 Frustrated Lewis Pairs" A Metal-Free Strategffor Hydrogenation Catalysis... 

I 77 Frustrated Lewis Pairs A Metal-Free Strategy for Hydrogenation Catalysis Table 11.1 Catalytic hydrogenation of imines with phosphonium borate catalysts [45]. 

We recently initiated efforts within our own laboratory to synthesize terpy-based ligands that incorporate appended Lewis acid/base pairs [36]. Motivated by metal-free systems of frustrated Lewis pairs (FLPs) which bind and form adducts with small molecules, we sought to couple the reactivity of FLPs to a transition-metal fragment to afford a metal Lewis acid/base triad (LABT). The combination of both partners with a transition-metal center opens up the possibiUty to synergistically use these systems for further activation and/or redox transformations - currently a hmitation of metal-free FLP systems. 

In another frustrated Lewis pair route, a highly enantioselective metal-free hydrogenation of imines uses a BlNAP-derived diene as a ligand hydroboration of the alkenes in situ with HB(CgF5)2 generates a chiral bis-borane catalyst. ... 

Kathmann et al. did determine reorientational correlation times for several amine bases in organic solvents based on both NMR relaxation and MD simulations as a test ability MD simulations and DFT calculations to explain the mechanism in complex reactions catalyzed by frustrated Lewis pairs (FLP) in metal free scission of H2. As the Debye-Stokes-Einstein (DSE) model gives only qualitative predictions, MD simulations are found valuable to validate the spectroscopic studies. 

A mechanistic study has enabled enantioselective (up to 87% ee) hydrosilylation of various imines for the first time using a novel frustrated Lewis pair (FLP) metal-free catalyst (Scheme 7). ... 

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