Fructose 3-diacetone

Following the study by Westheimer and Cohen [19] of the primary and secondary amine catalyzed dealdolization of diacetone alcohol which was proposed to occur through an essential imine intermediate. Speck and Forist [28] suggested that the S2une class of reaction may occur in aldolase. The first characterization of a stable covalent entity formed between substrate and enzyme was done by Horecker et al. [29] on transaldolase. This enzyme, which forms a stable complex with dihydroxy-acetone formed from the cleavage of fructose-6-P, was found to be susceptible to reduction by sodium borohydride. It was demonstrated that this adduct was formed... 

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