From Particles to Dosage Forms

Solvent Slice (kcaVmol) attmod (kcaVmol) Slice (kcal/mol) attmod (kcaVmol) Slice (kcaVmol) attmod (kcaVmol) Slice (kcaVmol) attmod (kcaVmol) 

TABLE 6.4 Modified Attachment Energies were Used to Generate Solvent-Modified Crystal Shape 

Results are in good agreement with experimental observations reported in Bunyan et al. [49]. 

A growing area of research has focused on the characterization of surface properties of particles however, this has typically being limited to the development of inhalation formulations [55]. Applications of surface techniques to study API/ excipient interactions to understand better the target attribute space for API particle properties are less routine. An area that is often overlooked when considering and nominating critical particle attributes for formulation and process design is the surface structural characteristics of the crystallized particles. The surface properties of crystalline particles will be driven by the crystal structure and chemical surface 

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