From Heterobicyclic Derivatives as Substrates

A variety of heterobicyclic derivatives have been used as substrates for the primary synthesis of phthalazines in this respect, isobenzofurans (including phthalic anhydride and the like) and isoindoles (including phthalimides, etc.) have been particularly heavily employed. The use of such bicyclic substrates is discussed in the following subsections, arranged alphabetically according to the parent system involved. 

This rare primary synthesis is represented by the rearrangement of 2-(6-azabicyclo[3.1.0]hexan-6-yl)-l,3-isoindolinedione (173) with addition of AcOH to give 2-(l-acetoxy-l,2-dimethylallyl)-l,4(2//,37/)-phthalazinedione (174) (AcOH, reflux, 24 h 95%).  

---

From Heterobicyclic Derivatives as Substrates 8.6.5. Cinnolines as Substrates... 

---