Friedlander-transfer hydrogenation reaction

Scheme 7.56 Three-component domino Friedlander-transfer hydrogenation reaction catalysed by chiral phosphoric acid catalysis and magnesium catatysis.

In 2012, Gong and co-workers reported an enantioselective three-component reaction based on an asymmetric relay catalytic domino Friedlander condensation-transfer hydrogenation reaction of 2-aminophenyl ketones. 

The first successful enantioselective intermolecular bromoesterifica-tion of carbo ylic acids has been realised by the use a 9-phenanthiyl substituted chiral phosphoric acid (145) as a catalyst (Scheme 50). Gong and co-workers have developed a relay reaction consisting of a catalytic Friedlander condensation and a transfer hydrogenation by using... 

Since chemisorbed ethylene disappears by initiation reaction with adsorbed hydrogen, pro-pagation reaction with surface-bound polymer chain, and polymer chain transfer with monomer (Fig. 9.8), one may write (Friedlander and Oita, 1957) ... 

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