Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Friedel-Crafts acylation, with lactones

Bycroft was able to achieve the synthesis of 110 via a slightly modified route (Scheme 1.22). ° Condensation of benzyl 7-hydroxyoctanoate (108) with 3,5-dimethoxyphenylacetyl chloride provided the expected diester 109. Hydrogenolysis of the benzyl ester gave the desired acid, which was induced to close to the lactone via intramolecular Friedel-Crafts acylation to afford 110. [Pg.21]

Other derivatives from carboxylic acids can be used as substrates in Friedel-Crafts acylation reactions, including anhydrides and esters. Toluene reacted with glutaric anhydride in the presence of aluminum chloride to give 197, which was used in the Vig et al. synthesis of curcumene ether.128 Lactones are also effective substrates in this cyclization, generating ketones. 129... [Pg.1091]

See other pages where Friedel-Crafts acylation, with lactones is mentioned: [Pg.187]    [Pg.187]    [Pg.267]    [Pg.267]    [Pg.32]    [Pg.9]    [Pg.267]    [Pg.22]    [Pg.754]    [Pg.754]    [Pg.32]    [Pg.32]    [Pg.12]    [Pg.226]    [Pg.754]    [Pg.142]    [Pg.734]    [Pg.734]    [Pg.446]    [Pg.107]    [Pg.54]    [Pg.734]   
See also in sourсe #XX -- [ Pg.1091 ]



SEARCH



Friedel Crafts with lactones

Friedel acylation

© 2024 chempedia.info