Friedal-Crafts reaction

For other Photo-Friedal-Crafts reactions , see (a) Martens, J., Praefcke, K., and Schulze, U, Intramoleulare Photo-Friedel-Crafts-Reaktionen ein neues Syntheses-Prinzip fUr Heterocyclen, Synthesis, 532-533, 1976 (b) Bryce-Smith, D., Deshpande, R., Gilbert, A., and Grzonka, ]., Acid-catalysis of photochemical reactions, Chem. Commun., 561-562, 1970. 

Suh et al.65 have reported a formal total synthesis of Mansonone F and this is described in Scheme 12. 5-Methoxy-a-tetralone (127) was converted to 1-methyl-5-hydroxy-naphthalene (128) by the standard organic reactions. Treatment of (128) with phenyl boronic acid, paraformaldehyde and propionic acid followed by catalytic hydrogenation yielded compound (129). This on alkylation gave the compound (130) which on alkaline hydrolysis was converted to acid. The acid halide underwent intramolecular Friedal-Crafts acylation affording an intermediate (131) whose transformation to Mansonone F has been accomplished by Best and Wege.59... 

Dichloro-phenoxy acetic acid undergoes Friedal-Craft s reaction with 4-butyryl chloride to yield the corresponding 4-butyryl analogue. This is subsequently subjected to Mannich reaction with formaldehyde and dimethylamino thereby introducing the methylene group caused by thermal decomposition, yields the official compound. 

Ferey et al. reported the Bronsted acid catalysis reaction on Friedal-Crafts benzylation using two different MIL-100 cations, Fe and Cr. Although the structure is identical [MjOFg gjCOH) , j5(H20)2(btc)J in both cases, the Fe-based MIL-100 showed superior performance over that the Cr-based MIL-100 and even smpassed the reported HY and HBEA zeolites [74], Irr MIL-100(Cr+ ), the Cr-OH sites showed mediirm Bronsted acidic strerrgth as corrfrrmed by low-temperature CO chemisorption studies [75],... 

Tungstated zirconia (WZr) is known as stable solid superacid which demonstrates high catalytic activity in numerous reactions with a proton transfer, especially in the hydroisomerization of n-C4 - C alkanes and Friedal-Crafts acylation of aromatic compounds. Relatively low specific surface area (< 70 m /g ) is a certain disadvantage of WZr. Also, on today the synthesis of solid acids which occupy intermediate position between zeolites with their acidity function values (Ho > -8) and superacids (Ho < -12) is of interest. The data on synthesis and catalytic study of mesoporous W03-Zr02-Si02 (WZrSi) oxide are presented in this communication. 

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