Fragment-based drug discovery future

Hannah V, Atmanene C, Zeyer D et al (2010) Native MS an ESI way to support structure-and fragment-based drug discovery. Future Med Chem 2 35 19... 

In the future, the ideas that underpin DOS, such as maximal chemical space coverage and efficient complex structure generation, will remain. However, we may also see DOS being used in a more focused way, directed toward the synthesis of novel or unusual chemical structures and architectures, and used more in the field of fragment-based drug discovery. Whatever directions DOS takes in the future, it is likely that solid-phase synthesis will remain integral to the field. 

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