Fractionation methods for particle size measurement

Commercially available fractionation methods include hydrodynamic chromatography (HDC), field flow fractionation (FFF) and disc centrifugation (DSC). One advantage of fractionation methods over nonfractionation methods is that the particles are separated physically according to size, prior to detection, which allows much higher resolution in determining the size distribution [40]. 

HDC and FFF are based on the separation by size of colloidal particles when they travel in Poiseuille flow through a narrow conduit. The larger particles travel faster than the smaller ones in HDC whilst the opposite occurs in FFF. Although FFF exhibits high efficiency of size separation, it is necessary to know the particle density in order to determine the particle size distribution, whereas HDC is density independent. 

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Fractionation. See also Plasma fractionation foam, 12 22 physical, 10 813-814 Fractionation methods, for particle size measurement, 18 139, 140-146 Fractionation process, in paper recycling, 21 441... 

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