Four Technical Syntheses of Ethyl R -2-Hydroxy-4-Phenylbutyrate

Blaser, H.-U., Eissen, M., Fauquex, P.R et al. (2003) Comparison of Four Technical Syntheses of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate. In Earge-Scale Asymmetric Catalysis (eds H.-U. Blaser E. Schmidt), pp. 91-104. WUey-VCH, Weinheim. 

Comparison of Four Technical Syntheses of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate... 

The asymmetric syntheses of various chiral compounds have already been compared with regard to their applicability on a technical scale. For example, Blaser and coworkers compared four technically feasible routes (A-D) for the large scale preparation of the chiral building block ethyl (R)-2-hydroxy-4-phenylbutyrate (10) (Scheme 4.13) [53]. The stereogenic centre is introduced via enantioselective reduction, either via biocatalytic or nonenzymatic methods. 

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