Tooling forming, solid-phase

For such an integrated research activity, differently modified peptides and proteins that carry modifications whose structure can be changed at will through synthesis are invaluable tools. Therefore, the synthesis of the lipidated peptides is an important theme. Lipidated peptides can typically not be accessed via standardized peptide synthesis methods. However, employing the synthetic tools developed and presented here, most types of lipidated peptides can now be synthesized and obtained in pure form. Even though solution-phase approaches still play a significant role in the synthesis of lipidated peptides, the recently developed solid-phase synthesis methods delineate the preferred strategy to access the majority of the required lipidated peptides. 

Within the pharmaceutical industry there has always been a need for sample purity. Any compound that is a potential drug candidate can only be fully characterised and tested once it is available in a pure form. There are many purification tools available for sample clean-up, e.g. flash chromatography, solid phase extraction, etc. 1-31. However, for the more complex purification problems where the desired compound and its associated contaminants have very similar polarities, structures, etc., preparative chromatography is the method of choice due to its superior separative capabilities. Preparative chromatography can also be scaled up from lens of milligrams to tens or even hundreds of grams of compound. The other main factor in favour of this technique is its ability to be tailored for most classes of compound. 

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