Formation of Pressor Substances by Amino Acid Decarboxylases

FORMATION OF PRESSOR SUBSTANCES BY AMINO ACID DECARBOXYLASES [Pg.534]

Imino acids are easily decarboxylated (188) and the amine could then be set free either through hydrolysis or through displacement by a second molecule of amino acid. None of the amino acid decarboxylases has been prepared in pure form, but Werle and Heitzer (186) have purified histidine decarboxylase about 35-fold. Recently, pyridoxal phosphate was shown to be the prosthetic group of several amino acid decarboxylases (7,74,162). For optimal yields on amines, incubations with amino acid decarboxylases were carried out under anaerobic conditions (91) in order to prevent the action of amine oxidase, and, in rat kidneys, also that of Z-amino acid oxidase. [Pg.535]

The formation of histamine, tyramine, hydroxytyramine and tryp-tamine (184) (as a result of tryptophan decarboxylase activity) is easily demonstrated pharmacologically through the action of these amines on blood pressure. Histamine lowers the blood pressure of cats, whereas the other [Pg.535]

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