Formamides Lewis basic organocatalysts

Formamides as Lewis-Basic Organocatalysts in Hydrosilylation of Imines... 

Some recent work has been directed towards the use of organocatalysts, in particular Lewis basic pipecolinic formamides, in the asymmetric hydrosilylation of N-arylimines. These catalysts function by activating the silane and exhibit broad substrate scope. For example formamide (3.186) effects enantioselective hydrosilylation of aryl-derived ketimines along with isopropyl-substituted imine (3.187) and a,P-unsaturated imine (3.188). 

With the increasing interest in developing catalysts able to be easily separated from the final product, many efforts have been devoted to the preparation of immobilized structures (for reviews on polymer-supported organocatalysts, see [201—204], for a more recent example, see also [205]). In this field, Kocovsky s group has also reported interesting Lewis base supported catalysts for the efficient asymmetric hydrosilylation of ketimines with silane 2. The first reported example was an N-methylvaline-derived Lewis basic formamide anchored to a polymeric support with... 

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