Formamides as Lewis Basic Organocatalysts in Hydrosilylation of Imines

Formamides as Lewis-Basic Organocatalysts in Hydrosilylation of Imines 

Entry Imine r r Catalyst (mol%) Solvent Temperature ( C) Yield (%) ee(%) (config.) 

Asafollotv up, Sun [11] showed that an expansion ofthe five membered ring ofthe proline moiety to a six membered ring, as in the pipecolinic derivative 18 (Table 4.1, entry 3) or in its piperazidine analogue 19 (entries 4 and 5), and further elaboration of the carboxylic terminus ofthe parent amino acid, as in 20 (entries 6 and 7), had a 

The reaction was carried out at 0.2 mmol scale with 2.0 equiv of ClaSill at 18°C for 16h in toluene unless stated otherwise see Ref. [12h]. 

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