Fondaparinux Coumarins

Prevention of DVT and PE (antithrombotic prophylaxis) is another common indication for UFH, LMWH or coumarin, especially following surgery or immobilizing trauma. Fondaparinux is approved for prevention of DVT and PE after hip and knee surgery, and following abdominal surgery. 

Discontinue agents that may enhance the risk of hemorrhage prior to initiation of fondaparinux therapy. If coadministration is essential, close monitoring may be appropriate. Coumarin may be affected by fondaparinux. 

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