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Fms-like tyrosine kinase

Fig. 9.8 Examples of rule-of-three compliant molecules that have biological activity better than 10 nM. Under each molecule, the following information is included molecule name, MW, ClogP, the biological activity type, value and target. Target names are as follows D3 and D4 - dopaminergic receptor types 2 and 3 AChE and BChE - acetyl- and butyryl-choline esterases PRa and PRb - progesterone receptor types A and B H] and H3, histamine receptor types 1 and 3 5-HT2a, 5-HT2b, 5-HT2c, 5-HT3, 5-HT4 - serotonin receptor subtypes 2A, 2B, 2C, and types 3 and 4 DAT, NET, 5-HTT - dopamine, norepinephrine and serotonin transporter proteins /X], /x.2, S, ki, ks - opioid receptor types mu-1, mu-2, delta, kappa-1 and kappa-3 5a-Rl and 5o -R2 - 5-alpha-reductase isozymes 1 and 2 Flt-1-fms-like tyrosine kinase receptor. Fig. 9.8 Examples of rule-of-three compliant molecules that have biological activity better than 10 nM. Under each molecule, the following information is included molecule name, MW, ClogP, the biological activity type, value and target. Target names are as follows D3 and D4 - dopaminergic receptor types 2 and 3 AChE and BChE - acetyl- and butyryl-choline esterases PRa and PRb - progesterone receptor types A and B H] and H3, histamine receptor types 1 and 3 5-HT2a, 5-HT2b, 5-HT2c, 5-HT3, 5-HT4 - serotonin receptor subtypes 2A, 2B, 2C, and types 3 and 4 DAT, NET, 5-HTT - dopamine, norepinephrine and serotonin transporter proteins /X], /x.2, S, ki, ks - opioid receptor types mu-1, mu-2, delta, kappa-1 and kappa-3 5a-Rl and 5o -R2 - 5-alpha-reductase isozymes 1 and 2 Flt-1-fms-like tyrosine kinase receptor.
Valter MM, Hugel A, Huang HJ, et al. Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-l)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. Cancer Res 1999 59(21) 5608-5614. [Pg.375]

Devries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. 1992. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255 989-991. [Pg.322]

In 43 patients, raised plasma concentrations of FLT3-L (an fms-like tyrosine kinase) in patients who had previously received chemotherapy predicted the stage of recovery of the bone-marrow compartment (40). FLT3-L seems to identify the hkelihood that the patient will have severe thrombocytopenia if additional cytostatic therapy is given. Knowledge of bone-marrow activity... [Pg.1037]

Pi, p2, <5, ki, l<3 - opioid receptor types mu-1, mu-2, delta, kappa-l, and kappa-3, 5a-Rl and 5a-R2 - 5-alpha-reductase isozymes 1 and 2, Flt-1 - fms-like tyrosine kinase receptor. [Pg.782]

Rosnet, 0. Mattel, M.G. Marchetto, S. Birnbaum, D. Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene. Genomics, 9, 380-385 (1991)... [Pg.601]

Fms-like tyrosine kinase/vascular endothelial growth factor receptor (FLT/Colony-stimulating factor receptor-likeA/EGFR)... [Pg.457]

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See also in sourсe #XX -- [ Pg.139 ]



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