Ropinirole Fluvoxamine

FLUVOXAMINE ANTIPARKINSON S DRUGS - ROPINIROLE t ropinirole levels Inhibition of CYP1 A2-mediated metabolism Watch for early features of toxicity (nausea, drowsiness)... 

Although the clinical relevance of this pharmacokinetic interaction has not been assessed, it would seem possible that the effects of ropinirole may be increased. The manufacturers suggest that if therapy with a known potent inhibitor of CYP1A2 is stopped or started during therapy with ropinirole, adjustment ofthe ropinirole dose may be required. The UK manufacturer specifically mentions cimetidine and fluvoxamine in addition to ciprofloxacin. For a full list of CYP1A2 inhibitors, see Table 1.2 , (p.4). 

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