Lansoprazole Fluvoxamine

C19 Omeprazole, esoprazole, lansoprazole, pantoprazole Omeprazole, fluvoxamine, moclobemide (use of PM vs. EM subjects) Rifampin... 

Fluvoxamine markedly inhibits the metabolisim of the proton pump inhibitors lansoprazole, omeprazole and rabeprazole in those of the CYP2C19 extensive metaboliser phenotype, producing levels comparable to those in poor metabolisers. However, these increases are probably of little clinical relevance. Theoretically escitalopram may have the same effect. Omeprazole may increase escitalopram levels. 

Lansoprazole Fluvoxamine increased the AUC and elimination half-life of a single 40-mg dose of lansoprazole by 3.8-fold and 3-fold, respectively. ... 

Yasui-Furukori N, Saito M, Uno T, Takahata T, Sugawara K, Tateishi T. Effects of fluvoxamine on lansoprazole pharmacokinetics in relation to CYP2C19 genotypes. J Clin Pharmacol (2004) 44,1223-9. 

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