Flurbiprofen Aluminium hydroxide

NSAIDs ANTACIDS 1. Magnesium hydroxide T absorption of ibuprofen, flurbiprofen, mefenamic acid and tolfenamic acid 2. Aluminium-containing antacids l absorption of these NSAIDs Uncertain These effects are 1 by taking these drugs with food... 

A small reduction in ketoprofen absorption occurred with aluminium-magnesium hydroxide, but dexketoprofen, ibuprofen and flurbiprofen were not affected, and naproxen showed a slight increase in rate and extent of absorption. Aluminium phosphate had no effect on ketoprofen absorption. 

Magnesium hydroxide appears to improve the rate of absorption of some acidic NSAIDs (which become more soluble as the pH rises) such as ibuprofen and flurbiprofen. Why this increased the gastric toxicity of ibuprofen in the one pharmacodynamic study is unclear. Sodium bicarbonate appears to have a similar effect on rate of absorption. Aluminium antacids do not produce soluble salts with these NSAIDs, and may therefore reduce the rate/extent of absorption. 

---