Imipramine Flupentixol

Tab. 5.27 Correlation coefficients between drug-membrane interaction parameters and biological data of the seven modifiers studied, (c/s- and trans-flupentixol, chlorpromazine, trifluoperazine, triflupromazine, imipramine, and quinacrine). Chlorpromazine was omitted from regression corresponding to the MCF-7/DOX cell line. Quinacrine data were not available for the P388/DOX cell line. (Reprinted from Tab. 2 of ref. 11 7, with permission from Bertelsmann-Springer)...

Also analyzed acebutolol, acetaminophen, alprazolam, amphetamine, atenolol, betaxolol, brotizolam, caffeine, camazepam, captopril, chloroquine, clobazam, clomipramine, cloth-iapine, clotiazepam, cloxazolam, cocaine, codeine, diclofenac, dihydralazine, dihydrocodeine, dihydroergotamine, diphenhydramine, domperidone, doxepin, droperidol, ergota-mine, ethyl loflazepate, fenethylline, fluoxetine, flupentixol, flurazepam, furosemide, gliclazide, hydrochlorothiazide, hydroxyzine, ibuprofen, imipramine, ketazolam, loprazo-1am, lorazepam, lormetazepam, maprotUine, medazepam, mepyramine, methadone, methaqualone, methyldopa, methylphenidate, metoclopramide, metoprolol, mexiletine, mianserin, midazolam, minoxidil, morphine, nadolol, nitrazepam, oxprenolol, papaverine, pentazocine, phenprocoumon, phenylbutazone, pipamperone, piritramide, practolol, pra-zepam, prazosin, promazine, promethazine, propoxyphene, propranolol, prothipendyl, quinine, sotalol, sulpride, thioridazine, trazodone, triazolam, trimipramine, tripelennamine, lyramine, verapeunil, yohimbine... 

Flupentixol did not inhibit the metabolisini of imipramine in two patients but high levels of imipramine and its metabolite, desipramine, were found in another patient. 

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