Fluorous Concepts in Combinatorial Chemistry

Fluorous chromatography is a simple means of separating different perfluoralkyl homologs of structurally similar compounds and a unique opportunity for combinatorial chemistry. 

This concept of fluorous mixture synthesis has been used and extended for the preparation of compound libraries of interest in medicinal chemistry [17, 20-22]. 

H2O 4 1, leaving the fluorous benzyl alcohol adsorbed by the fluorous phase to be re-used in another reaction cyde. 

Fluorous scavengers do not necessarily need to form a covalent bond with the species they have to remove into the fluorous phase. For example, lightly fluorous N,N -dialkyl ureas can bind to perfluorocarboxyl ic acids by hydrogen 

purification adsorption of product on acidic ion exchange resin and subsequent FSPE 

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