Fluorophosphoric acid monoesters

Halogenophosphoric acid esters s. Fluorophosphoric acid monoesters, Phosphorohalidates Halogenophosphorus compounds... 

Fluorophosphoric acid monoesters from phosphoric acid monoesters... 

Uridylic acid dissolved in dry dioxane by addition of tri-n-butylamine, then l-fluoro-2,4-dinitrobenzene added, and kept 72 hrs. at 37° 2, 3 -cyclouridylic acid. Y 92-95%. J. Stockx and M. Van Montagu, Bl. Soc. chim. Belg. 71, 634 (1962) fluorophosphoric acid monoesters cf. Synth. Meth. 17, 584. 

In 1948, a preparation of DFP was described by Saxmders and Stacey of Cambridge, United Kingdom (Saunders and Stacey, 1948), and a US patent was filed (McCombie et al., 1949). In 1949, another patent was filed for production of mono and dialkyl fluorophosphates. These were produced by treating alkyl polyphosphates with HF and were called dialkoxy phosphoryl monofluoride (Lange, 1949). The monoesters were purported to have low toxicity in mammals but showed fungicidal properties. For that time period in the open literature, preparation of DFP by other complicated methods has been reported, as well as studies of its effects on the nervous systems and as a potential treatment of human diseases. Further efforts regarding the application of fluorophosphoric acid and its salts were focused on the prevention of dental disease (i.e., as an additive in toothpaste). 

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