Fluoroalkyl copper compounds

Fluoroalkyl copper compounds, 17 143, 144 a-Fluoroalkylidinehydrazines, 33 167 2-Fluoroalky 1 -2 phospha-1,3-dialky 1 -1,3-diaze-tidinones, synthesis of, 14 87 Fluoroanions, trivalent, uranium, 34 94—95 Fluoroantimony compounds, 7 17 Huoroaryl copper compounds, 17 143, 144 Fluoroberyllates anhydrous, 14 267-276 aqueous chemistry of, 14 274-278 glasses, 14 265-267 preparation and properties of, 14 265-267... 

The incorporation of fluorine into biologically active compounds can greatly enhance their potency fluoroalkyl phosphonates are isosteres of the natural phosphonate monoesters. The alkylation chemistry of a-fluoro- and a,a-difluoro-alkyl phosphonates has been reported. Burton and Sprague have described the alkylation of (diethoxyphosphoryl)difluoromethylzinc bromide with allylic halides the reaction is catalyzed by copper(I) bromide. The alkylation of (diethoxyphosphoryl)dichloromethyllithium was reported by Normant and coworkers. The products can be transmetallated and further alkylated. 

Perfluoroalkylcopper reagents have received more attention than perhaps any other perfluorinated organometallic compounds. They can be prepared from per-fluoroalkyl iodides and copper metal in polar solvents (such as DMSO, DMS,... 

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