Stereochemistry fluoroacetamidation

Control of the stereochemistry of the product has proved problematic when fluoroacetates or fluoroacetamides are used in this process. However, introduction... 

Control of the stereochemistry of the product has proved problematic when fluoroacctatcs or fluoroacetamides are employed in this general process. However, introduction of a fluoroalkyl substituent allows almost complete recovery of the very high diaslereoselectivilies reported in the reactions of hydrocarbon amides27 to give products 25.27... 

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