Fluoroacetaldehyde Streptomyces cattleya

Scheme 8. The conversion of L-threonine 12 and fluoroacetaldehyde 11 to 4-FT 2 and acetaldehyde catalysed by the PLP enzyme threonine transaldolase from Streptomyces cattleya [18].

C. Schaffrath, C.D. Murphy, J.T.G. Hamilton, D. O Hagan, Biosynthesis of fluoroace-tate and 4-fluorothreonine in Streptomyces cattleya. Incorporation of oxygen-18 from [2- H,2- 0]-glycerol and the role of serine metabolites in fluoroacetaldehyde biosynthesis, J. Chem. Soc. Perkin Trans. 1 (2001) 3100-3105. 

Moss SJ, Murphy CD, Hamilton JTG, McRoberts WC, O Hagan D, Schaffrath C, Harper DB (2000) Fluoroacetaldehyde A Precursor of Both Fluoroacetate and 4-Fluorothreonine in Streptomyces cattleya. Chem Commun 2281... 

Murphy CD, Moss SJ, O Hagan D (2001) Isolation of an Aldehyde Dehydrogenase Involved in the Oxidation of Fluoroacetaldehyde to Fluoroacetate in Streptomyces cattleya. Appl Environ Microbiol 67 4919... 

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