Fluoro methyllithium

The 1 la-methyI-9, lly5-epoxide (41) is the sole product of the reaction of the 9a-fluoro-11-ketone (40) with methyllithium. ... 

Scheme 6.83 Generation of l-thia-2,3-cyclohexadiene (406) from exo-6-bromo-endo-6-fluoro-2-thiabicyclo[3.1. OJhexane (405) by methyllithium and trapping of406 by styrene and 1,3-butadiene.

Later, in Lausanne, further mixed metal reagents were tested. LIC-KOR confirmed its role as a faithful workhorsein numerous situations, e.g. the metalation of 2- or 4-fluoroanisole and 2- or 4-fluoro-l-(methoxymethoxy)benzene . The mixture of methyllithium and potassium ieri-butoxide ( LIM-KOR ) gives optimum results if... 

An efficient and inexpensive method for the substitution of an allylic hydroxyl group with fluorine, without allylic rearrangement and elimination consists of treating an allylic alcohol with methyllithium followed by p-toluenesulfonyl fluoride, lithium fluoride and 12-crown-4.6 By this method, geranyl fluoride, neryl fluoride, cinnamyl fluoride, ( , )-farnesyl fluoride, retinyl fluoride and 4-fluoro-2-methyl-6-(4-tolyl)hept-2-ene are prepared. 

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