4-Fluoro-4’ -hydroxybenzophenone

A solution of 4-fluoro-4 -hydroxybenzophenone (5.00 g, 23 mmol) in NMP (45 mL) is added over a 24 h period using a syringe pump. When addition is complete, the reaction is stirred for a further hour at 145-150°C and then cooled to room temperature. 

Scheme 4 Polymerization of potassium salt of 4-fluoro-4 -hydroxybenzophenone...

The rate constant of the polymerization of a potassium salt of 4-fluoro-4 -hydroxybenzophenone was calculated by using linear free energy relationships based on the rate constants of the reaction of substituted 4-halogenobenzophenones with the potassium salts of substituted 4-hydroxybenzophenones (Scheme 4) [6,7]... 

OH Preparation by reaction of bromine with 3-fluoro- — / — 4-hydroxybenzophenone in acetic acid [461]. 

Preparation by reaction of 60% nitric acid with 4 -chloro-5-fluoro-2-hydroxybenzophenone in acetic acid at r.t. for 30 min (84%) [472]. 

N.B. In the patent, this compound was erroneously named 3-fluoro-4 -chloro-2-hydroxybenzophenone (assay 21, page 13) [1037]. 

Preparation by partial alkylation of 4 -fluoro-2,4-di-hydroxybenzophenone with a propyl halide in the presence of an alkali [1109],... 

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