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2-fluoro-ara-AMP

Fludarabine is an analog of the purine adenine. It interferes with DNA polymerase to cause chain termination and inhibits transcription by its incorporation into RNA. Fludarabine is dephosphorylated rapidly and converted to 2-fluoro-Ara-AMP (2-FLAA), which enters the cells and is phosphorylated to 2-fluoro-Ara-ATP, which is cytotoxic. Fludarabine is converted rapidly to 2-FLAA. The pharmacokinetics of 2-FLAA... [Pg.1285]

BAN, USAN. 2-Fluoro-9-(5-0-phospho-no-P-D-arabinofuranosyl)-9Yi-purin-6-amine, 9CI. F-ara AMP-2. NSC 312887 [75607-67-9]... [Pg.446]

See other pages where 2-fluoro-ara-AMP is mentioned: [Pg.876]    [Pg.1302]    [Pg.876]    [Pg.544]    [Pg.876]    [Pg.1302]    [Pg.876]    [Pg.544]    [Pg.113]   
See also in sourсe #XX -- [ Pg.876 ]



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